Scientists develop new protocol for measuring background levels of drugs in forensic

first_img Source:https://www.nist.gov/news-events/news/2018/09/new-protocol-measuring-background-levels-drugs-crime-labs Reviewed by James Ives, M.Psych. (Editor)Sep 27 2018When crime lab chemists handle evidence that contains illegal drugs, trace amounts of those drugs are inevitably released into the laboratory environment. When chemists scoop a bit of powder to test it, for instance, microscopic particles can become airborne and later settle on nearby surfaces. Particles can also be spread by touch. To some degree, this is an unavoidable byproduct of the testing process, and it can result in detectable background levels of drugs in the lab.Now, scientists at the National Institute of Standards and Technology (NIST) and the Maryland State Police Forensic Sciences Division have developed a protocol for measuring those levels and used their new protocol at three forensic chemistry labs. Their findings were published today in Forensic Chemistry.Best practices recommend regular cleaning of surfaces to remove drug residues, but few labs currently monitor background levels. That might have to change as super-potent drugs like fentanyl, the synthetic opioid driving the nationwide overdose epidemic, become more common. Small amounts of fentanyl are often mixed into other drugs to boost their potency, and labs may have to increase the sensitivity of their instruments to detect those small amounts. If background levels are too high, that can potentially affect the test results reported by the lab.”If I run a sample and it has fentanyl, I want to be sure that fentanyl came from the sample and not from background levels in my lab,” said NIST research chemist Ed Sisco, the lead author of the study.To measure those levels, the authors swabbed laboratory surfaces in the same way that airport security agents might swab a passenger’s hands or luggage. At the airport, that swab would go into an instrument that tests for traces of explosive residue. In this study, the authors tested the swabs for traces of narcotics. They swabbed laboratory benches, balances, telephones and door handles. They also swabbed outside the lab space, in evidence-receiving areas and office spaces. To ensure that the measurements reflected routine conditions at the lab, no unscheduled cleaning took place prior to testing.To identify which drugs were present, the researchers used a technique called Direct Analysis in Real Time Mass Spectrometry (DART-MS). They then used Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS) to measure how much of each drug was present. These instruments are more sensitive than the ones crime labs use for everyday drug casework.Related StoriesResearchers completely eliminate all traces of HIV from infected miceA Portable Solution for the On-scene Identification of KratomAntibiotic combination effective against drug-resistant Pseudomonas”If you push your sensitivity enough, you’ll find narcotics on almost everything,” and not just in chemistry labs, according to NIST research chemist and co-author Marcela Najarro. The authors cited a 2011 study that found detectable amounts of cocaine on 75 percent of shopping carts, ATM machines and other frequently touched surfaces in public places.At the labs they tested, the researchers detected at least 13 different substances, including fentanyl, heroin, cocaine, oxycodone and methamphetamine. For fentanyl, the average level detected was two nanograms, or billionths of a gram, per square centimeter, and the highest level was 55 nanograms per square centimeter. “That level of background wouldn’t affect measurements at most labs because most labs don’t look down that far when testing evidence,” said co-author Amber Burns, a forensic chemist with the Maryland State Police. “But knowing those numbers can be important if a lab is considering an increase in their sensitivity.”Some other interesting findings: The balances that chemists use to weigh evidence contained up to 10 times more drug residue than other surfaces. This suggests one relatively easy way that labs can reduce background levels. Also, different labs had different contamination profiles. One of the labs had higher levels of cocaine while another had more opioids, which reflected the mix of cases handled at each lab.The authors detailed their protocol so that other labs could reproduce it, with recommendations on how to swab and where, and how to analyze and report the results. In a follow-up study, they will investigate lower-cost methods so labs can more easily afford to conduct regularly scheduled tests. They also plan to partner with experts from the National Institute for Occupational Safety and Health, who will assess the potential effects of background levels on workplace safety.In the meantime, they hope their research will provide a reliable protocol that any lab can follow. “You can’t completely eliminate background levels of drugs,” Sisco said. “But you can measure it to make sure it’s low enough, and that it stays low.”last_img read more

Study Reducing mutated Huntington disease protein restores psychiatric impairments in mice

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 4 2018New research from the University of British Columbia suggests that reducing mutated Huntington disease protein in the brain can restore cognitive and psychiatric impairments in mice.Huntington disease (HD) is a genetic, progressive disorder that causes mental decline, psychiatric problems and uncontrolled movements. The disease is caused by mutant huntingtin (HTT) protein, with symptoms appearing in adulthood and worsening over time.Scientists delivered gene therapy treatment to mice in the form of pieces of DNA, called antisense oligonucleotides, that decreased production of the toxic HTT protein. With this intervention, the researchers found mice regained cognitive performance and became less anxious and depressed.”Being able to restore cognitive function and improve anxiety in an ill mouse is very exciting,” said study lead author Amber Southwell, assistant professor at Burnett School of Biomedical Sciences, who conducted the research as a postdoctoral research fellow at the UBC Centre for Molecular Medicine and Therapeutics.Related StoriesRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalInhibition of p38 protein boosts formation of blood vessels in colon cancerStudy reveals how protein mutation is involved in Christianson syndrome”Most Huntington disease studies have focused on motor performance, so we wanted to assess mood, learning and memory that represent significant burdens.”There is no cure for Huntington disease, but researchers are working towards preventative treatment, so people who have the HTT gene never develop the disease. Scientists hope people may one day be able to access ongoing treatment, much like those who suffer from asthma.Michael Hayden, study senior author, University Killam Professor, senior scientist and founder of the UBC Centre for Molecular Medicine and Therapeutics, said the symptom that is most apparent in HD patients is the uncontrolled dance like movements, but the psychiatric symptoms and cognitive decline are particularly debilitating.”This study reinforces the potential of huntingtin lowering not only on the movement disorder but also on psychiatric and cognitive features, assuming adequate lowering of huntingtin in the appropriate regions is achieved,” said Hayden.Approximately one in 7,000 people in Canada has HD and every child of a person with the disease has a 50 per cent chance of inheriting the gene that causes the illness.​Source: https://news.ubc.ca/2018/10/03/lowering-levels-of-mutant-protein-that-causes-huntington-disease-can-restore-cognitive-function-in-mice/last_img read more

Worlds first medical imaging scanner produces diagnostic scan of the whole human

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 20 2018EXPLORER, the world’s first medical imaging scanner that can capture a 3-D picture of the whole human body at once, has produced its first scans.The brainchild of UC Davis scientists Simon Cherry and Ramsey Badawi, EXPLORER is a combined positron emission tomography (PET) and x-ray computed tomography (CT) scanner that can image the entire body at the same time. Because the machine captures radiation far more efficiently than other scanners, EXPLORER can produce an image in as little as one second and, over time, produce movies that can track specially tagged drugs as they move around the entire body.The developers expect the technology will have countless applications, from improving diagnostics to tracking disease progression to researching new drug therapies.The first images from scans of humans using the new device will be shown at the upcoming Radiological Society of North America meeting, which starts on Nov. 24th in Chicago. The scanner has been developed in partnership with Shanghai-based United Imaging Healthcare (UIH), which built the system based on its latest technology platform and will eventually manufacture the devices for the broader healthcare market.”While I had imagined what the images would look like for years, nothing prepared me for the incredible detail we could see on that first scan,” said Cherry, distinguished professor in the UC Davis Department of Biomedical Engineering. “While there is still a lot of careful analysis to do, I think we already know that EXPLORER is delivering roughly what we had promised.Badawi, chief of Nuclear Medicine at UC Davis Health and vice-chair for research in the Department of Radiology, said he was dumbfounded when he saw the first images, which were acquired in collaboration with UIH and the Department of Nuclear Medicine at the Zhongshan Hospital in Shanghai.”The level of detail was astonishing, especially once we got the reconstruction method a bit more optimized,” he said. “We could see features that you just don’t see on regular PET scans. And the dynamic sequence showing the radiotracer moving around the body in three dimensions over time was, frankly, mind-blowing. There is no other device that can obtain data like this in humans, so this is truly novel.”Badawi and Cherry first conceptualized a total-body scanner 13 years ago. Their idea was kick-started in 2011 with a $1.5 million grant from the National Cancer Institute, which allowed them to establish a wide-ranging consortium of researchers and other collaborators. And it got a giant boost in 2015 with a $15.5 million grant from the NIH. The funding allowed them to team up with a commercial partner and get the first EXPLORER scanner built.Related StoriesResearch sheds light on sun-induced DNA damage and repairCancer killing capability of lesser-known immune cells identifiedSugary drinks linked to cancer finds studyCherry said he expects EXPLORER will have a profound impact on clinical research and patient care because it produces higher-quality diagnostic PET scans than have ever been possible. EXPLORER also scans up to 40 times faster than current PET scans and can produce a diagnostic scan of the whole body in as little as 20-30 seconds.Alternatively, EXPLORER can scan with a radiation dose up to 40 times less than a current PET scan, opening new avenues of research and making it feasible to conduct many repeated studies in an individual, or dramatically reduce the dose in pediatric studies, where controlling cumulative radiation dose is particularly important.”The tradeoff between image quality, acquisition time and injected radiation dose will vary for different applications, but in all cases, we can scan better, faster or with less radiation dose, or some combination of these,” Cherry said.For the first time, an imaging scanner will be able to evaluate what is happening in all the organs and tissues of the body simultaneously. For example, it could quantitatively measure blood flow or how the body takes up glucose everywhere in the body. Researchers envision using the scanner to study cancer that has spread beyond a single tumor site, inflammation, infection, immunological or metabolic disorders and many other diseases.UC Davis is working closely with UIH to get the first system delivered and installed at the EXPLORER Imaging Center in leased space in Sacramento, and the researchers hope to begin research projects and imaging patients using EXPLORER as early as June 2019. The UC Davis team also is working closely with Hongcheng Shi, director of Nuclear Medicine at Zhongshan Hospital in Shanghai to continue and expand the scope of early human studies on the scanner.”I don’t think it will be long before we see at a number of EXPLORER systems around the world,” Cherry said. “But that depends on demonstrating the benefits of the system, both clinically and for research. Now, our focus turns to planning the studies that will demonstrate how EXPLORER will benefit our patients and contribute to our knowledge of the whole human body in health and disease.” Source:https://www.ucdavis.edu/last_img read more

Researchers understand reproductive behaviors and olfactory abilities of African pouched rat

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 25 2019Thousands of people – many of them children – are hurt or killed by land mines each year, so finding these devices before they explode is critical.There is a surprising champion of detection: the African giant pouched rat. Native to sub-Saharan Africa, the pouched rats are large – they can grow up to 3 feet long, including the tail – but are still too small to set off the land mines. They have an exceptional sense of smell – they are also used to detect tuberculosis – but scientists know very little about their biology or social structure, and they’re difficult to breed in captivity.”We wanted to understand their reproductive behaviors and olfactory capabilities, because they have been so important in humanitarian work,” said Alex Ophir, assistant professor of psychology in the College of Arts and Sciences.Cornell University researchers have found that the pouched rats’ reproductive system is unlike any other species. They report their findings in a study, “Anogenital Distance Predicts Sexual Odour Preference in African Giant Pouched Rats,” published Jan. 17 in Animal Behaviour. Co-authors were Ophir, postdoctoral researcher Angela Freeman and Michael Sheehan, assistant professor of neurobiology and behavior.For male rats searching for a mate, identifying which adult females are reproductively available, or patent, is critical. Female pouched rats have extremely delayed sexual development. When the researchers looked at whether male pouched rats have a preference for the scent of females who are patent, they found something unexpected.Related StoriesDaily intake for phosphates in infants, children can exceed health guidance valuesNew network for children and youth with special health care needs seeks to improve systems of carePuzzling paralysis affecting healthy children warns CDCMales with longer anogenital distances (AGD) could detect the difference between patent and non-patent females and preferred the scent of patent females. AGD, an indirect marker of masculinization, is determined by developmental exposure in utero to sex hormones like testosterone. Males with shorter AGD showed no preference for patent females. Similarly, patent females showed a preference for the scent of masculinized males, while non-patent females did not.This is the first time it’s been shown that longer AGD is associated with more efficient communication and signal processing, according to Freeman, first author of the paper.Ophir noted that being able to distinguish viable from non-viable partners in a split second has long-term repercussions for reproductive success among the species.”It is amazing to think that in utero experiences can lock in the ability of these males to detect differences in female reproductive availability,” Ophir said. “Our results raise interesting evolutionary questions, like how does natural selection operate on characteristics that are largely determined by chance features of the uterine environment?”In other rodent species, patency is dictated by the estrous cycle. But that does not seem to be the case with pouched rats.”This kind of patency change is different from basically every other rodent that’s been studied up until this point,” said Freeman. “Further studies to understand this process will help explain why breeding pouched rats is so difficult in captivity.” Source:http://news.cornell.edu/stories/2019/01/scientists-tackle-breeding-challenges-land-mine-finding-ratslast_img read more

New HIV drug that is like a Swiss Army knife of immunotherapies

first_imgCytomegalovirus CMV in human cell. Image Credit: Kateryna Kon / Shutterstock Related StoriesHIV therapy leaves unrepaired holes in the immune system’s wall of defenseReprogramming cells to control HIV infectionStudy: HIV patients continue treatments if health care providers are compassionateThe team included blood samples of two dozen men from the Pitt’s Men’s study. This large study was again a part of the Multicenter AIDS Cohort Study (MACS). Researcher Jan Kristoff said, “The MACS participants were vital to the success of this study. You have to collect a lot of blood to find T cells latently infected with functional HIV in people on ART (anti retroviral treatment) — it could be as few as 1 out of every 10 million cells. So the men would sit for as long as four hours hooked up to a machine that processed their blood and came back multiple times to give more samples.”They isolated dendritic cells that could kill the HIV virus. Robbie Mailliard explained that these cells, “hand off the ball and dictate the plays, telling other immune cells where to go and what to fight.” From these cells they created “antigen-presenting type 1-polarized, monocyte-derived dendritic cells,” or MDC1. Mailliard said, “Without adding any other drug or therapy, MDC1 were then able to recruit killer T cells to eliminate the virally infected cells. With just MDC1, we achieved both kick and kill – it’s like the Swiss Army knife of immunotherapies. To our knowledge, this is the first study to program dendritic cells to incorporate CMV to get the kick, and also to get the kill.”The team found success with this approach and saw that MDC1 could coax the latent or hidden HIV virus in to the blood and then kill it effectively. This new therapy they add could be the “all in one” immunotherapy for HIV infected persons and could mean that patient no longer need to take life-long ART against HIV. At present they are seeking funding for large scale human trials with their approach. By Dr. Ananya Mandal, MDApr 7 2019Reviewed by Kate Anderton, B.Sc. (Editor)HIV is a tricky virus that causes a unique phenomenon where the virus hides within the immune cells of patients when they are on treatment with the antiretroviral therapy (ART) drugs. When they are off the drugs, the virus comes back. Researchers have now come up with a new drug that can push out the virus from its hiding and then kill is once and for all. The results of the preliminary study were published last week in the journal EBioMedicine.The team from University of Pittsburgh that developed this immunotherapy said that this is the first step towards developing a vaccine against HIV. Early results of the drug in lab settings have shown promise they add. Human trials are still some time away, they agree. Researcher Robbie Mailliard said, “It’s like the Swiss Army knife of immunotherapies.”The team explains in the study how they engineered an immunotherapy and called it MDC1. The drug is capable of attacking both HIV and Cytomegalovirus (CMV). CMV is a common co-infection with HIV affecting 95 percent HIV positive individuals. Researcher Charles Rinaldo, a professor and chair of Pitt Public Health’s Department of Infectious Diseases and Microbiology, explained, “The immune system spends a lot of time keeping CMV in check; in some people, 1 one out of every 5 T cells are specific to that one virus. That got us thinking – maybe those cells that are specific to fighting CMV also make up a large part of the latent HIV reservoir. So we engineered our immunotherapy to not only target HIV, but to also activate CMV-specific T helper cells.”last_img read more

Researchers identify gut protein essential for neonatal mice to fight infections

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 8 2019Scientists have identified a protein critical to the immune system development and antibody production in mice, which could contribute to understanding the gut defense mechanism in infants.A joint team from Hokkaido University and Keio University has identified a gut protein essential for neonatal mice to fight infections, according to research published in the Journal of Experimental Medicine. The insight could help understand how infants develop their own intestinal immune systems after weaning.The gut is constantly exposed to potentially harmful bacteria that come with food and is home to naturally occurring intestinal bacteria that help fend off pathogens and produce vitamins. To maintain a healthy balance, microfold cells or ‘M’ cells in the gut lining absorb antigens, which are foreign molecules from outside the body. This absorption triggers production of antibodies, which bind to and neutralize pathogens.Related StoriesResearch sheds light on sun-induced DNA damage and repairAlternate cell growth pathway could open door to new treatments for metastatic cancersNanoparticles used to deliver CRISPR gene editing tools into the cellInfants do not have their own immune systems and receive maternal antibodies through breastfeeding to keep harmful bacteria at bay. However, it has been unclear how young children develop M cells and antibodies during the weaning phase.In the current study, a group led by Shunsuke Kimura of Hokkaido University, and Nobuhide Kobayashi and Koji Hase of Keio University found that a protein called Sox8 was specifically expressed by M cells. Using florescence and imaging techniques, they also found that the protein was present in both young and mature M cells, indicating its consistent involvement during the cell development stages.Furthermore, the team found that Sox8 directly promotes the production of an antigen receptor, GP2, that is only found in fully matured M cells and enables antigen uptake.Conversely, lack of Sox8 in mice led to reduced expression of GP2 and therefore reduced antigen uptake, suggesting that Sox8 is responsible for the maturation of M cells. In the mice lacking Sox8, production of antibodies was significantly reduced one week after weaning, indicating that the protein is indispensable for the immediate establishment of immune system after weaning.”Future studies should investigate genes regulated by this protein in order to completely understand the molecular mechanisms underlining the intestinal immune system,” says Shunsuke Kimura. “We hope that our study may one day help develop preventive measures such as vaccines against gut infections among infants,” Koji Hase added.Source: https://www.global.hokudai.ac.jp/blog/identifying-a-key-player-in-gut-defense-development/last_img read more

Climate emergency Shift towards plantbased diets vital to achieve net zero emissions

first_img Encourage the nation to adopt an increasingly plant-based diet, Implement policies for public sector institutions such as schools, hospitals and care homes to offer a good vegan meal as standard on menus every day, as part of its Catering for Everyone campaign, Provide financial and practical help to farmers who wish to move away from farming animals towards growing crops for human consumption, as part of its Grow Green campaign. The letters are urging politicians to recognize that in addition to meeting the needs of people with various dietary requirements, a strong vegan offering promotes inclusivity, sustainability and good nutrition.Will Gildea, Campaigns and Policy Officer at The Vegan Society, said: The Vegan Society is imploring politicians to “translate this announcement into action” by adopting policies that encourage plant-based diets, offer vegan food in public sector canteens and support farmers in moving away from farming animals.Formal letters signed by the charity’s chief executive have been sent to the Labor Party, Liberal Democrats, UK Parliament, the Scottish National Party and the Welsh Government.They state that increased knowledge and uptake of plant-based foods are required not only for climate change mitigation but for public health too as it can relieve pressure on the NHS.The charity also highlights that achieving net zero emissions is only possible via a shift towards plant-based diets as the production of meat, dairy and eggs generates much higher levels of emissions.George Gill, Chief Executive at The Vegan Society, said: Oxford University research found that adopting a plant-based diet is the “single biggest thing” individuals can do for the planet and EAT-Lancet – the latest international, peer-reviewed project of its kind – observed that planetary boundaries and human health require a move towards plant-based diets.The United Nations found that livestock alone account for more greenhouse gas emissions than all global transportation combined, and recently called for for far-reaching reductions in emissions from sectors including agriculture.Last month’s research from Harvard University proved the UK would be still be able to sustain itself by producing enough protein and calories if it stopped farming animals for meat, dairy and eggs. The charity is asking political parties to take three steps: Source:https://www.vegansociety.com/ May 9 2019Major political parties are being urged to include veganism at the center of food and farming policies after declaring a national climate emergency. We are campaigning for vegan options to become standard across the public sector to ensure there is always a suitable food option for everyone.Government should also be supporting farmers who wish to towards sustainable arable farming or ecological restoration, which would help it deliver on its promise of public money for public goods.On an individual level, we can make a difference by eating a plant-based diet – anyone who is interested can sign up for the seven-day Plate Up for the Planet challenge.” It is widely recognized that eating animal products has a huge environmental impact, yet this is not at all incorporated into policy.Animal agriculture has not taken its share of emissions and it’s becoming increasingly clear that we will not be able to meet the Paris Agreement unless we make a national shift towards plant-based diets.We are calling on political parties to act upon their promise and take a bold step to overcome the climate emergency by implementing policies encouraging truly sustainable, plant-based diets.”last_img read more

Lipidlowering drugs are underutilized for preventing atherosclerotic cardiovascular disease

first_imgRelated StoriesProbiotic containing common gut bacterium could halve cardiovascular disease ratesResearch paves way for new treatment to protect people from cardiovascular diseaseSubclinical cardiovascular disease linked to higher risk of falling in older adultsThe authors recommend several strategies to help reduce this treatment gap: standardizing care through ASCVD-specific admission orders; implementing risk classification tools and corresponding statin treatment recommendations in lab orders; electronic medical record review; and a follow-up lipid profile at the time of discharge. US clinical guidelines have also recently highlighted new lipid-lowering therapies, including PCSK9 inhibitors, as an option for lipid management among very high risk ASCVD patients to lower risk of cardiovascular events.”This study showed in a large contemporary Canadian population that statins are under-used to lower cholesterol. Increasing uptake of statins could drastically reduce the number of heart attacks, strokes, and death in patients with established vascular disease,” explained co-investigator Todd Anderson, MD, Director, Libin Cardiovascular Institute; Professor & Head, Department of Cardiac Sciences; Professor in the Department of Medicine, Merck Chair, Cardiovascular Research, University of Calgary, Cumming School of Medicine, Calgary, AB, Canada.In an accompanying editorial, lead author Robert T. Sparrow, MD, Faculty of Medical Science, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, discusses the challenges of non-compliance, pointing out that statins are often the subject of negative news stories and internet postings that minimize their extremely well-established benefits and exaggerate their adverse effects to a degree not seen with other cardiovascular drugs. Therefore, patient education must often counter pre-existing biases introduced by the media.”The results of this study bring to light an important principle: time and energy, not knowledge, are the real barriers to statin prescribing. The many health needs and perceptions of ASCVD patients, short appointments, and competing demands on physician time all combine to impede statin prescribing,” commented Dr. Sparrow. “Reminder systems to identify undertreated patients and tools to streamline the treatment discussion process and encourage patient empowerment through education can lead to robust improvements. It is time to lighten the burden on physicians and encourage implementation of systems and programs around them to help improve their prescribing practices.”Low-density lipoprotein cholesterol (LDL-C) is sometimes called “bad” cholesterol because a high LDL level contributes to a build-up of plaque in the arteries, a condition called atherosclerosis. Measuring LDL-C in the blood is an important indicator in the development and management of ASCVD. The most commonly used medication to treat high LDL-C is a statin, which helps reduce LDL levels by interfering with cholesterol production in the liver. Source:ElsevierJournal reference:Chen, G. et al. (2019) Treatment and Low-Density Lipoprotein Cholesterol Management in Patients Diagnosed With Clinical Atherosclerotic Cardiovascular Disease in Alberta. Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2019.04.008. Reviewed by James Ives, M.Psych. (Editor)Jul 16 2019Statins, the most commonly used effective lipid-lowering drugs, are significantly underutilized to treat lipid abnormalities in patients with and at risk for atherosclerotic cardiovascular disease (ASCVD), according to a retrospective study of more than 280,000 patients in Alberta, Canada. Investigators report in the Canadian Journal of Cardiology, published by Elsevier, that only two-thirds of these patients were receiving moderate/high-intensity statins, and of the ones treated, more than a third are under-treated based on the fact that they did not achieve recommended low-density lipoprotein cholesterol (LDL-C) levels at follow-up testing.It should be noted that numerous studies have documented the benefits of appropriate statin use in at-risk populations, demonstrating reduction in atherosclerotic disease and the prevention of adverse outcomes like heart attacks, strokes, and deaths.”Despite the known benefits of statins, a significant treatment gap persists in patients with ASCVD or at high risk of developing ASCVD. We need to conduct additional research to better understand contemporary management of these patients,” said lead investigator Guanmin Chen, PhD, MD, MPH, Medlior Health Outcomes Research Ltd; Department of Community Health Sciences and Libin Cardiovascular Institute of Alberta; and O’Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.Investigators assessed current patterns of lipid-lowering therapy for the management of LDL-C among 281,665 patients identified with ASCVD, based on administrative health system data for 2011-2015 from the province of Alberta. A retrospective study was conducted by linking multiple health system databases to examine clinical characteristics, treatments, and LDL. The objectives of the study were to characterize the proportion of patients with ASCVD and a statin prescription; to describe the intensity level of statins prescribed; and to determine the proportion of statin users who achieved recommended levels of LDL-C.LDL-C was assessed at the first measurement (index test) and second measurement (follow-up test) during the study period. LDL-C levels were evaluated based on the 2016 Canadian Cardiovascular Society guideline recommendations for achieving less than 2.0 mmol/L or a 50 percent reduction. Statin therapies were categorized as low-, moderate-, and high-intensity.Among the individuals identified with ASCVD during the study period, 78 percent had an index LDL-C test and 66 percent were prescribed lipid-lowering therapy. Most patients receiving any lipid-lowering therapy were on moderate-/high-intensity statins. Failure to achieve guideline-recommended levels of LDL-C was common among patients using moderate- or high-intensity statin therapy; and 40 percent of patients did not adhere to their treatment regimens. Given the remarkable treatment gap identified in these patients at-risk for ASCVD, the current study results may help to facilitate new strategies to reduce the number of untreated or under-treated patients. Additional research is needed to assess the reasons for the observed treatment gaps and their effects on morbidity, mortality, and other important outcomes, such as health-related quality of life, functional status, as well as healthcare resource utilization and costs.”Dr. Guanmin Chenlast_img read more

Chronic kidney disease patients are excluded from clinical trials

first_imgRelated StoriesResearchers investigate whether hypertension poses health risk to older kidney donorsDiabetes drug reduces cardiovascular events and kidney problems, study findsNew imaging probe allows earlier detection of acute kidney failureWhen it comes to treatment of other illnesses and/or comorbidities, CKD patients should also have the same right to receive the best possible treatment as any other patients. However, the truth is that many new therapies are not tested on this subgroup, which means that CKD patients are unable to benefit from promising therapies. The International Society of Nephrology charged the research community with enrolling 30% of CKD patients by 2030. By encouraging the inclusion of CKD patients in high-quality clinical trials we can ensure they receive equal opportunity to receive evidence-based prevention and treatment of the disease. ‘It is a fact that the efficacy and the safety of treatments tested on patients without CKD cannot be assumed in CKD patients, and similarly that withholding treatment due to the presence of CKD may significantly and unfairly disadvantage those affected’, explains Professor David Harris, Past-President of the International Society of Nephrology. ‘We need studies that include CKD patients.’The Kidney Health Initiative, the American Society of Nephrology’s public-private partnership with the US Food and Drug Administration, addresses this issue through its “Overcoming Barriers to Including Kidney Disease Patients in Cardiovascular Trials”. The project aims to understand the barriers to involving patients with kidney diseases into cardiovascular trials, with a focus on patients with advanced chronic kidney disease (stage 4) and end-stage renal diseases and identify strategies to overcome these challenges. The workgroup intends to submit their findings to a peer-reviewed medical journal in Summer 2019.’It is time for a change in clinical research practice’, confirms Professor Mark D. Okusa, Past-President of the American Society of Nephrology (ASN). ‘The already large and growing group of kidney patients cannot be ignored any longer in clinical trials.’ This is the reason why ASN (https://www.asn-online.org ), ERA-EDTA (http://web.era-edta.org ) and ISN (https://www.theisn.org ) have collaboratively launched an information campaign that aims to bring about thisparadigm change. Source:ERA-EDTA The fact of the matter is that many innovative treatments fail to reach our patients. Let’s take SGLT inhibitors, a new group of antidiabetic drugs, as an example. We know from studies that these substances may protect kidney function, but they have not been tested in CKD patients with an eGFR below 30 ml/min. This means that kidney patients are excluded from therapies that might slow down the progression of CKD.”Professor Carmine Zoccali, President of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Reviewed by James Ives, M.Psych. (Editor)Jul 10 2019Kidney diseases affect 850 million people worldwide, a figure twice as high as that of diabetes. Yet patients with chronic kidney disease (CKD) are still being excluded from clinical trials. This gives rise to severe problems, because many beneficial therapies cannot be authorized by regulatory authorities for this subgroup of patient, this means that the therapies in question cannot be prescribed for CKD patients. It is crucial, however, that CKD patients be eligible for new treatments, especially in the fields of diabetes, cardiovascular disease, cancer, and liver disease.CKD is bidirectionally linked to cardiovascular disease, in that CKD engenders a high risk of cardiovascular complications, while heart disease may induce or aggravate CKD. CKD is also bidirectionally linked to neoplasia because, regardless of other factors, cancers or treatments targeting cancers may engender CKD, while CKD may predispose to cancer. Furthermore, there is a strong relationship between CKD and diabetes: over a third of all dialysis patients have suffered from diabetes for a long time, and their need for dialysis treatment results from the fact that diabetes has damaged the kidneys (a condition called diabetic nephropathy). As a public health epidemic, CKD patients require innovative therapies. It is highly problematic, therefore, if CKD patients cannot benefit from innovative therapies for diabetes, cancer or cardiovascular diseases.Since 1964 the ERA EDTA maintains a Registry of Dialysis and Transplantation in Europe. Starting about 10 years ago, this Registry has extended its research to pre-dialysis CKD by establishing a consortium of existing CKD cohorts in Europe and in 2007 provided expert advice to the European commission by contributing to the European Global Health Report by putting in focus the CKD epidemic. In recent years the ERA EDTA has directly funded clinical trials in renal diseases and in dialysis patients.last_img read more

Lesscool Facebook losing youth at fast pace survey

With mom, dad and grandma signing up in increasing numbers, Facebook is losing younger users in the United States at a faster pace than previously estimated, researchers said Monday. © 2018 AFP A report by eMarketer said Snapchat is drawing youths away from Facebook at a quicker clip than Facebook-owned Instagram.Facebook is still growing in the US market, according to research firm, mainly due to increases in usage by older age groups.The report is the latest to highlight Facebook’s problem with attracting and keeping young people, who have long been a core user base for the world’s biggest social network.The research firm said it expected the first-ever decline in the 18-24 age group in the US, a drop of 5.8 percent this year.It also said that for the first time since its research began, less than half of the 12-17 age group in the United States would be on Facebook, with a 5.6 percent drop in that segment. The under-12 age group meanwhile will see a decline of 9.3 percent this year, eMarketer said.The same trend is expected to continue into 2019 and 2020, with declines in all segments of US users under 25, the report added.Facebook will lose an estimated two million users under 25 this year, with Snapchat and Instagram the main beneficiaries.The report said Snapchat will add 1.9 million users under 25 in 2018 and Instagram will add 1.6 million.Snapchat, which is known for its disappearing messages, will continue to have more users aged 12 to 24 than Instagram, the researchers said.But Snapchat could end up facing a similar problem as it seeks to increase its user base and reach all ages.”Snapchat could eventually experience more growth in older age groups, since it’s redesigning its platform to be easier to use,” eMarketer analyst Debra Aho Williamson said. “The question will be whether younger users will still find Snapchat cool if more of their parents and grandparents are on it. That’s the predicament Facebook is in.”Facebook remains the most popular social network in the US market with an estimated 169.5 million users this year, according to eMarketer.But faster-growing Instagram will be used by 104.7 million Americans and Snapchat will reach 86.5 million users, according to the forecast.Last year, eMarketer predicted Facebook would see declines among some youths for the first time in its history.A report last year by investment firm Piper Jaffray showed Snapchat is the preferred social network for US teens, with 47 percent using the platform. Explore further Snapchat leads augmented reality gains: researchers Credit: CC0 Public Domain Citation: Less-cool Facebook losing youth at fast pace: survey (2018, February 12) retrieved 18 July 2019 from https://phys.org/news/2018-02-less-cool-facebook-youth-fast-pace.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Suspected Austria bitcoin fraud sparks Europewide probe

© 2018 AFP A suspected Austrian bitcoin scam may have spread across Europe Citation: Suspected Austria bitcoin fraud sparks Europe-wide probe (2018, February 15) retrieved 18 July 2019 from https://phys.org/news/2018-02-austria-bitcoin-fraud-europe-wide-probe.html “Hundreds” of people across Austria have complained of being defrauded by the “Optioment” scheme dealing in the digital currency, Christina Ratz, spokeswoman for the Vienna public prosecutor’s office, told AFP on Thursday. Die Presse, a daily, put the number of possible victims as high as 10,000.Two Austrians have been identified as being accused of fraud in the case, with more suspects possible as the case progresses, Ratz said.Investors were promised returns of up to four per cent per week for investing bitcoins into the opaque scheme, which initially did offer dividends before suddenly collapsing in November.In January Austria’s financial market watchdog brought Optioment to the attention of prosecutors, saying it suspected fraud, a pyramid scheme or violations of capital markets regulations.The scheme appears to have used “multi-level marketing” in order to grow, with investors encouraged to find new clients themselves.”I got my whole family involved. We put around 50 bitcoins in. The money’s gone. I’m sure of it,” one young woman told a joint investigation by Die Presse and the public ORF TV station.Another investor recalled an event promoting the scheme at the Pyramide hotel in Voesendorf, just south of Vienna: “They ran on stage and started running around, they were playing air guitar. It felt like a cult”.Reports of the number of bitcoins invested in the scheme go as high as 12,000, worth around 95 million euros at current value, or more than double that at the peak of the boom in the currency.Lawyers acting for the Austrians identified as the frontmen for the scheme issued a statement saying their clients did not handle any cash or bitcoins themselves, Die Presse reports. The paper reported the men as saying that they were themselves defrauded by two mysterious figures behind the scheme, a Danish man, Lucas M., and a Latvian, Alex P. Authorities investigating a suspected bitcoin-related scam centred in Austria have asked Interpol to help determine whether there might be perpetrators – and victims – of the scheme across Europe. Explore further Texas man pleads guilty in NY bitcoin securities fraud case This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Kasich orders all Ohio roads open to smart vehicle testing

Citation: Kasich orders all Ohio roads open to smart vehicle testing (2018, May 9) retrieved 18 July 2019 from https://phys.org/news/2018-05-kasich-ohio-roads-smart-vehicle.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Republican Gov. John Kasich (KAY’-sik) is opening all of Ohio’s public roads to smart vehicle testing. Kasich signed an executive order Wednesday authorizing autonomous vehicle research to take place across the state. The order also lays out safety parameters for such projects and creates a voluntary pilot program linking local governments to participating companies.The order extends Kasich’s efforts to make Ohio a hub of smart vehicle research and development. It urges participating projects to sign up with DriveOhio. That’s a new state office he created in January to coordinate several state offices through a “one-stop shop” for autonomous or connected vehicle developers.The order requires participating vehicles to meet certain safety requirements and to be capable to comply with all Ohio traffic laws. It reserves Kasich’s right to suspend non-compliant projects. © 2018 The Associated Press. All rights reserved. Explore further Ohio to invest $15M on corridor for testing smart vehicles read more

Facebook cuts adtarget options to thwart discrimination

first_img Citation: Facebook cuts ad-target options to thwart discrimination (2018, August 22) retrieved 18 July 2019 from https://phys.org/news/2018-08-facebook-ad-target-options-thwart-discrimination.html Explore further Facebook is eliminating the ability to target ads based on certain criteria such as race or ethnic affiliation amid concerns this could lead to discrimination Facebook said Tuesday it is cutting more than 5,000 ad-targeting options to prevent advertisers from discriminating based on traits such as religion or race. US regulators target Facebook on discriminatory housing adscenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The shift eliminates the ability to direct Facebook ads at people based on ethnicity, beliefs, political affinity or other data that could be considered sensitive or personal.”While these options have been used in legitimate ways to reach people interested in a certain product or service, we think minimizing the risk of abuse is more important,” the leading online social network said in an online post.The announcement came less than a week after the US Department of Housing and Urban Development accused Facebook of breaking the law by letting landlords and home sellers use its ad-targeting system to discriminate against potential buyers or tenants.A formal complaint filed by HUD contended that Facebook advertisers were able to target offers of homes available for rent or sale based on factors such as race, religion, gender, nationality or disabilities.”We’re committed to protecting people from discriminatory advertising on our platforms,” Facebook said.Some media reports this year noted that advertisers could choose to target ads at African Americans, Hispanics or other demographic groups—or exclude them, to effectively market products or services to whites.Most of the terms removed were in a category that let advertisers designate who they wanted excluded from seeing marketing messages.For example, Facebook advertisers can no longer opt to prevent ads from being shown to user who have expressed interest in topics such as Passover, Islam, Buddhism or Native American culture.Facebook added that all US advertisers will need to certify that they accept the social network’s non-discrimination policy. Previously, the compliance certification was required only of those posting housing, employment or credit ads.The certification is intended to educate advertisers regarding “the difference between acceptable ad targeting and ad discrimination,” according to the social network.Facebook planned to eventually expand the measure to more countries, but provided no timeline and insisted the move was not a reaction to the HUD complaint.”No, we’ve been building these tools for a long time and collecting input from different outside groups,” a Facebook spokesman said of the notion.The HUD complaint filed on Friday came after an investigation confirmed that advertisers on Facebook could exclude categories such as people who expressed interest in assistance dogs, parenting, China or the Bible, according to the agency.Facebook prohibits discrimination and has strengthened its systems during the past year to protect against advertisers misusing targeting capabilities, a spokesman told AFP. © 2018 AFPlast_img read more

Chinas Huawei to sell stake in underseacable unit

first_img US President Donald Trump has attacked Huawei in recent months, urging allies to boycott its products and blacklisting the Chinese firm from buying some US software. Undersea cables are vital to global internet traffic.The 51 percent stake in Huawei Marine Networks will be bought by Hengtong Optic-Electric, an optical-cable manufacturer based in eastern China’s Jiangsu province, according to a filing with the Shanghai Stock Exchange.Huawei Marine Networks is a joint venture between Huawei and UK-based undersea cable firm Global Marine Systems. Huawei Marine claims on its website to be involved in around 90 projects, from the Pacific to the Atlantic, totalling more than 50,000 kilometres (30,000 miles) of undersea cables.Washington suspects that Huawei, which was founded by former People’s Liberation Army (PLA) engineer Ren Zhengfei, has ties to China’s military and thus poses a security threat.The Trump administration warns that Huawei networks carrying data around the could be accessed and manipulated by Beijing using security backdoors built into the company’s equipment.Huawei has repeatedly denied any connection to China’s government or that it poses any security threat.Reached by AFP, a Huawei spokesperson said the company had no immediate comment on the status of Huawei Marine.Hengtong Optic-Electric’s stock exchange filing said the company was purchasing the stake from Huawei Technologies Co, Huawei’s corporate parent. Founded by Ren in 1987, Huawei has risen to become the world leader in telecom networking equipment and one of the top smartphone manufacturers alongside Samsung and Apple.But the US Commerce Department last month placed Huawei and dozens of affiliates on an “entity list” on grounds of national security, a move that curbs its access to US-made components it needs, though a 90-day reprieve was later issued.A number of countries have also blocked Huawei from working on their mobile networks and companies have stepped away from the firm following the US ban, citing legal requirements. Huawei Marine Networks is a joint venture between Huawei and UK-based undersea cable firm Global Marine Systems US ban has ‘no effect’ on Huawei’s aviation business: official Huawei will sell its majority share in a submarine cable unit, the stake’s buyer announced Monday, amid a US-led drive to isolate the Chinese telecom giant from global information networks over spying fears. © 2019 AFPcenter_img Explore further Citation: China’s Huawei to sell stake in undersea-cable unit (2019, June 3) retrieved 17 July 2019 from https://phys.org/news/2019-06-china-huawei-stake-undersea-cable.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Robot traps ball without coding

first_img Recently developed impedance-controlled robots have opened up a new era of robotics based on the natural elasticity of human muscles and joints, which conventional rigid robots lack. Robots with flexible joints are expected to be able to run, jump hurdles and play sports like humans. However, the technology required to teach such robots to move in this manner has been unavailable until recently.The KIST research team became the first in the world to develop a way of teaching new movements to impedance-controlled robots using human muscle signals. With this technology, which detects not only human movements but also muscle contractions through sEMG, it has now become possible for robots to imitate movements based on human demonstrations.Dr. Kee-hoon Kim’s team has succeeded in using sEMG to teach a robot to quickly and adroitly trap a rapidly falling ball before it comes into contact with a solid surface or bounces too far to reach—similar to the skills employed by soccer players. SEMG sensors were attached to a man’s arm, allowing him to simultaneously control the location and flexibility of the robot’s rapid upward and downward movements. The man then “taught” the robot how to trap a rapidly falling ball by giving a personal demonstration. After learning the movement, the robot was able to skillfully trap a dropped ball without any external assistance.This research outcome, which shows that robots can be intuitively taught to be flexible by humans, has attracted much attention, as it was not accomplished through numerical calculation or programming of the robot’s movements. This study is expected to help advance the study of interactions between humans and robots, bringing us one step closer to a world in which robots are an integral part of our daily lives.Kim said, “The outcome of this research, which focuses on teaching human skills to robots, is an important achievement in the study of interactions between humans and robots.” Citation: Robot traps ball without coding (2019, June 20) retrieved 17 July 2019 from https://phys.org/news/2019-06-robot-ball-coding.html Provided by National Research Council of Science & Technology Why R2-D2 could be your child’s teacher sooner than you think Explore further SEMG sensors were attached to a man’s arm, allowing him to simultaneously control the location and flexibility of the robot’s rapid upward and downward movements. Credit: Korea Institute of Science and Technology (KIST) Demonstration of a robot to trap ball without coding. Credit: Korea Institute of Science and Technology (KIST) Dr. Kee-hoon Kim’s team at the Center for Intelligent & Interactive Robotics of the Korea Institute of Science and Technology (KIST) developed a way of teaching “impedance-controlled robots” through human demonstrations using surface electromyograms (sEMG) of muscles, and succeeded in teaching a robot to trap a dropped ball like a soccer player. A surface electromyogram is an electric signal produced during muscle activation that can be picked up on the surface of the skin. This research outcome shows that robots can be intuitively taught to be flexible by humans, as it was not accomplished through numerical calculation or programming of the robot’s movements. Credit: Korea Institute of Science and Technology (KIST) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Remains of Napoleons OneLegged General Found Under Russian Dance Floor

first_img A portrait of Charles Etienne Gudin, who fought in Napoleon’s Grande Armée. Credit: Photo12/UIG/Getty Images Photos: Mass Graves Hold 17th-Century Prisoners of War An excavation in a peculiar place — under the foundation of a dance floor in Russia — has uncovered the remains of one of Napoleon Bonaparte’s favorite generals: a one-legged man who was killed by a cannonball more than 200 years ago, news sources report. Gen. Charles Etienne Gudin fought with Napoleon during the failed French invasion of Russia in 1812. On July 6 of this year, an international team of French and Russian archaeologists discovered what are believed to be his remains, in Smolensk, a city about 250 miles (400 kilometers) west of Moscow, according to Reuters.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65920-napoleon-general-found-in-russia.html?jwsource=cl已复制直播00:0000:3500:35  After his death at age 44 on Aug. 22, 1812, Gudin got star treatment. His name was inscribed on the Arc de Triomphe in Paris, his bust was placed at the Palace of Versailles, a Paris street was named after him and, as a sentimental gesture, his heart was removed from his body and placed in a chapel at the Père Lachaise Cemetery in Paris. [Photos: Archaeologists Excavate Battlefield from Napoleonic Wars] The researchers said that several clues suggested that the skeleton they found under the dance floor belongs to Gudin, who had known Napoleon since childhood. Both men attended the Military School in Brienne, in France’s Champagne region. Upon hearing of Gudin’s death, Napoleon reportedly cried and ordered that his friend’s name be engraved on the Arc de Triomphe, according to Euronews. Photos: A 400-Year-Old War Grave Revealed Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndo Records from the 1812 Russian invasion note that Gudin’s battlefield injuries required him to have his left leg amputated below the knee, Euronews reported. Indeed, the skeleton in the coffin was missing its left leg and showed evidence of injury to the right leg — details that were also mentioned in those records, the archaeologists said, according to Reuters. Moreover, it was “with a high degree of probability” that the remains the team uncovered belonged to an aristocrat and a military veteran of both the French Revolutionary and Napoleonic wars, they said, according to Reuters. “It’s a historic moment not only for me, but for I think for our two countries,” French historian and archaeologist Pierre Malinovsky, who helped find the remains, told the Smolensk newspaper Rabochiy Put (Worker’s Journey), according to Reuters. “Napoleon was one of the last people to see him alive, which is very important, and he’s the first general from the Napoleonic period that we have found.” The general has known living descendants, so researchers plan to test the skeleton for DNA. That way, they’ll be able to say for sure whether the remains are those of Gudin. Gudin, however, is hardly the only French fatality recently found in Russia. Earlier this year, scientists did a virtual facial reconstruction of a man in his 20s who was slashed in the face with a saber and died during the invasion of Russia. 19 of the World’s Oldest Photos Reveal a Rare Side of Historylast_img read more

Sigh of relief for Govt as monthly rituals at Sabarimala conclude

first_imgDevotees form human shield around the Sabarimala Ayyappa Temple following rumours that woman intruded into the temple premises on Monday night. Photo: H Vibhu   –  The Hindu October 22, 2018 COMMENT SHARE religion and belief SHARE SHARE EMAIL sabarimala Kerala Published on Our BureauWith the Sabarimala hill shrine closing down on Monday after the monthly rituals, the State government and the Devaswom Board (temple administration) will be able to heave a collective sigh of relief. However, the temple will reopen for monthly rituals on November 5 and close the next day, only to resume on November 16 for the annual Mandala Puja that will last until December 27. The opening of the temple on October 17 the first time after the Supreme Court ordered that women of all ages be allowed inside, had seen the shrine of Lord Ayyappa and the surrounding holy hillock slip under the tightest security cover ever. CLIMB BIDS BLOCKEDPassions ran high with stray attempts by women of restricted age between 9 and 50, surrounded by a tight police cordon, to scale the steep climb but finding spirited resistance by hundreds of chanting devotees. This continued even on Monday when a woman form Kozhikode was sought to be escorted by the police but stopped on the way by devotees. The police managed to prevent a potential law and order situation after advising the woman to return.Devotees in their hundreds also forced four other women from Andhra Pradesh after they ventured up to Neelimalai, midway into the arduous pilgrim trek. Given this, closure of the shrine would be a godsend for the government and the Devasom Board. And the Board proposes to use this ‘cool-off period’ to revisit the Supreme Court order with review petitions pending already. So filing another petition will be futile exercise, according to A Padmakumar, President of the Board. STATUS UPDATE REPORTInstead, the Board is thinking of filing a ‘status update’ explaining the situation on ground after the temple opened for the first time after the Supreme Court pronounced its verdict. It has already started gathering expert views, including from the best legal luminaries, in the matter and would likely decide on how to present its case in the Supreme Court, Padmakumar said. “The Board is now engaging its standing counsels in the High Court of Kerala. It will intervene decisively in the matter, and, unlike its initial posturing, will now seek to conserving the tradition and rituals associated with the shrine,” he added.A meeting of the board to be held on Tuesday would decide on the contents of the status update, including whether to incorporate the views of the Tantri (high priest) family and the Pandalam palace. (E.o.m.) COMMENTSlast_img read more

22K Indias Anshula Kant is World Bank MD and CFO

first_imgJuly 13, 2019 01:33 IST India’s Anshula Kant is World Bank MD and CFO Updated: July 12, 2019 22:41 IST Previous StoryU.S. regulators approve $5 billion Facebook settlement over privacy issues: source International Washington DC, Next Story PRINT Share Article Printable version | Jul 13, 2019 8:34:29 PM | https://www.thehindu.com/news/international/indias-anshula-kant-is-world-bank-md-and-cfo/article28415426.ece Related Articles Please use a genuine email ID and provide your name, to avoid rejection. Washington DC, Anshula Kant. File  | Photo Credit: MAIL AAA July 12, 2019 22:41 IST Sriram Lakshman 2 Recommended for you The article had erroneously stated that Anshula Kant was the first woman MD of The World Bank SUBSCRIBE TO OUR DAILY NEWSLETTER FigLeaf AppComplete Online Anonymity Is One Click AwayFigLeaf App|SponsoredSponsoredUndoGundry MDTop U.S. Surgeon: This Is What Happens To Dark Spots (When You Do This Every Morning)Gundry MD|SponsoredSponsoredUndoProgressive$699 average annual savings for drivers who switch and save.Progressive|SponsoredSponsoredUndoKelley Blue Book10 Electric Cars That Last the LongestKelley Blue Book|SponsoredSponsoredUndoThrone: Free Online GamesPlay this for 1 minute and see why everyone is addicted!Throne: Free Online Games|SponsoredSponsoredUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore Supplement|SponsoredSponsoredUndoFisher InvestmentsAre You Ready for Retirement? 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Close XPolice arrest Indian captain of Iran tankerU.S. Secretary of Commerce Wilbur Ross says changing FDI in e-commerce rules troubling to American firmsPakistan won’t open airspace until India withdraws fighter jets from airbases, says Pakistan Aviation SecretaryRussian S-400 defense systems arrive in Turkey Child suicide bomber kills 5 at wedding in AfghanistanSuicide bomber kills five at wedding party in eastern AfghanistanChild suicide bomber kills 5 at Afghan wedding New Zealand police buy back weaponsDespite threat of U.S. sanctions, Turkey continues to receive Russian S-400 air defence parts Bangladesh charges former Chief Justice with graft Police arrest Indian captain of Iran tankerU.S. Secretary of Commerce Wilbur Ross says changing FDI in e-commerce rules troubling to American firmsPakistan won’t open airspace until India withdraws fighter jets from airbases, says Pakistan Aviation SecretaryRussian S-400 defense systems arrive in Turkey Child suicide bomber kills 5 at wedding in AfghanistanSuicide bomber kills five at wedding party in eastern AfghanistanChild suicide bomber kills 5 at Afghan wedding New Zealand police buy back weaponsDespite threat of U.S. sanctions, Turkey continues to receive Russian S-400 air defence parts Bangladesh charges former Chief Justice with graft Police arrest Indian captain of Iran tankerU.S. Secretary of Commerce Wilbur Ross says changing FDI in e-commerce rules troubling to American firmsPakistan won’t open airspace until India withdraws fighter jets from airbases, says Pakistan Aviation SecretaryRussian S-400 defense systems arrive in Turkey 1 / 10 July 13, 2019 01:33 IST Related TopicsBusinessInternational © THG PUBLISHING PVT LTD. The World Bank Group on Friday announced that Anshula Kant, an Indian national, has been appointed its next MD and CFO. Ms. Kant will be the first woman CFO of the Bank.“Anshula brings more than 35 years of expertise in finance, banking, and innovative use of technology through her work as CFO of the State Bank of India,” World Bank Group president David Malpass said via a statement.“She’s excelled at a diverse array of leadership challenges including risk, treasury, funding, regulatory compliance and operations. I look forward to welcoming her to our management team as we work to increase our effectiveness in supporting good development outcomes.” Play VideoPlayUnmuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window.The media could not be loaded, either because the server or network failed or because the format is not supported.Caption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneMs. Kant will be responsible for financial and risk management and report to Mr. Malpass. Her duties will include risk management and financial reporting and she will work with the Bank’s CEO to mobilise financial resources.Ms. Kant has holds an Honours degree in Economics from Lady Shri Ram College and a post-graduate degree in Economics from the Delhi School of Economics. Comments will be moderated by The Hindu editorial team. Comments that are abusive, personal, incendiary or irrelevant cannot be published. We may remove hyperlinks within comments. Next Story Child suicide bomber kills 5 at wedding in Afghanistan Updated: Ms. Kant will be the first woman CFO of the Bank Comments Sriram Lakshmanlast_img read more